Why Choose HiComp
-
Manufacturing Excellence
Two-Week Turnaround
Multi-Material Manufacture
Cost-Effective Scaling
High-Capacity Facility
500+ Projects Delivered
-
Integrated OOC Solution
Ready-to-Use Devices
Pre-validated with standard tissue models.
Fully Customized Chips
Tailored to your model, delivered fast.
Chip-Compatible Cell Seeding
Co-culture, 2D/3D formats, and organoids.
Fabrication & Integration
PDMS/plastic expertise, sensors, and perfusion.
System Development
Electronics, pumps, and plug-and-play modules.
Start Your Project
How It Works
Path A: Manufacturing (from CAD)
1
DFM Review
We optimize your CAD for yield, materials, and bonding.
2
Prototype Fabrication
Rapid build in PDMS, plastic, or glass (as soon as 2 weeks).
3
Scale Production
Transition to consistent, high-volume manufacturing with QC.
Path B: Model Development (From Biology)
1
Feasibility Check
2
System Design
3
Fabrication & Assembly
We align on biological goals and confirm technical feasibility.
Microfluidics, controls, and sensor integration.
Device production, sterilization, and surface treatment.
4
Model Validation
Cell seeding, culture, and functional verification data.
Final Deliverables
-
Validated Cell Model & Report
-
OoC Devices (Ready for use)
-
Optimized Media & Cells
-
Instrument Setup (Plug-and-play for drug development)
Request a Quote for OOC Chip Manufacturing
Request a Proposal for OOC Model Development
Case Studies
-
Substrate Versatility
Available in plastic, glass, and hybrid materials
-
Finish Customization
Sterilization, pyrogen-free treatment, barcoding, coating, custom packaging
Case Study 1
Microplate-Based NASH Liver Organoids for Hepatotoxicity Testing
We build custom microwell plates compatible with 6-well to 384-well formats, with engineered substrates and microfeatures to control spheroid or organoid formation and support high quality imaging.
-
Microwell Capabilities
Microwell/micropillar sizes down to 2 μm
-
Custom Pipette Tips
Custom pipette tips available to match microplate layout and automation
Establish NASH Model with Human Liver
Primary human hepatocytes co-cultured with stromal cells form stable organoids in our plates; after induction, they’re ready for drug treatment and readouts.
Liver cells were combined and seeded into a micro-well plate. After several days of culture, round and clear organoids were formed. On Day 7, treatments were introduced to induce NASH. The images above show the successful formation of NASH organoids from three individual donors. Following one week of induction, the NASH organoids were ready for drug treatments and related applications.
NASH Liver Model for Hepatotoxicity Test
We can discriminate between hepatotoxic and non-hepatotoxic analogs—e.g., clozapine is toxic while amoxapine is not—across multiple donors. Clozapine (red bars) exhibited clear hepatotoxic effects, while amoxapine (blue bars) showed no signs of liver toxicity.
This model effectively distinguishes between hepatotoxic and non-hepatotoxic structural analogues, yielding consistent results across multiple donors. This demonstrates robust biology paired with engineered substrates.
-
Integrated PDMS OoC Device Assembly
We assemble PDMS organ-on-chip devices by embedding the PERFECT membrane within multilayer microfluidic structures that are cured, aligned, and bonded under controlled conditions. This process yields a clear, sealed device with stable flow paths and robust membrane integration suitable for a wide range of barrier and co-culture models.
-
Customization and Application Support
We work with researchers and industry partners to design OoC devices tailored to specific biological, mechanical, and imaging needs, with full control over channel layout, membrane porosity, materials, and device geometry. This approach supports rapid early development and delivers reproducible devices for longitudinal or higher throughput studies.
-
High-performance Membranes
Conventional membranes such as PDMS, PC, and PET are often too thick, have poorly controlled porosity, limit imaging, and absorb small molecules in ways that bias assays. Our parylene C membrane platform solves these issues by offering precise control over thickness, porosity, and pore geometry, producing thin, transparent, and low absorption membranes suited for dynamic barrier models.
-
Parylene-based PERFECT Filter
Our PERFECT filter is fabricated using a parylene molding and etching process that creates uniform, free standing membranes with well defined honeycomb pore lattices and tunable porosity. This design provides high mechanical flexibility, large effective filtration areas, and consistent transport properties for endothelial and epithelial interfaces or other models that require reliable mass transfer.
Case Study 2
Microfluidic Organ-on-a-Chip (OoC) for Modeling Tissue Barrier Function
We build custom organ-on-a-chip (OoC) devices that integrate high precision microfluidic channels, engineered membranes, and mechanically tunable materials to reproduce tissue barrier function, parenchymal tissue behavior, and multi organ interactions. Our platform supports both flexible research prototyping and reliable, scalable manufacturing.
FAQ
9920 Pacific Heights Blvd, STE 150, San Diego, CA
PDMS · Injection Molding · MEMS - One Partner
858.252.5959