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PDMS Microfluidics
From Prototype to Production

  • HiComp delivers production-grade PDMS devices with a clean finish, precise thickness control, and injection molding level quality.
  • Support organ-on-chip, organoids, cell culture, diagnostics, liquid biopsy, and drug discovery with  speed and industrial-scale yield.

Applications

Organ-on-a-Chip
(OOC) & MPS

Organ-on-a-Chip
  • Gas-permeable and optically  clear

  • Bubble-free substrates preserve viability.

  • Electrode & membrane integration supported.

Organoids & 3D Cell Culture

Organoids
  • Soft, biocompatible interfaces; 

  • 2-8 layer bonding; 

  • Uniform thickness for imaging.

Liquid Biopsy

Liquid Biopsy
  • High-resolution, high-aspect-ratio replication

  • High fidelity microfeatures for capture/sorting.

Assay Development

Assay Development & Ramp-up
  • Rapid design iteration;

  • Multilayer bonding;

  • Various surface treatment; 

  • Ready to scale.

Process flow -Lab vs. HiComp at Scale

Typical Lab Setup

HiComp Production

PDMS manufacturing

Manual weigh & hand-mix; variable degassing

Metered mixing and controlled vacuum degassing in dedicated equipment for bubble free bulk PDMS and batch-to-batch consistency.

2.PDMS Mixing

 4.Bonding

PDMS Mixing

6.Assembly

Ports & Reservoirs
Bonding

Benchtop tubing; manual assembly

Single-piece plasma bonding by hand

Batch bonding in fixtures and high yield.

Documented assembly (tubing, membranes, electrodes) or cartridge integration for high-volume packaging.

Casting / Molding
Assembly

1.Master Mold

SU-8 photoresist on wafer; open tool; limited lifetime

Mother mold Tooling by using 3D printing, CNC, SU-8, and silicon etch; long-life resin master for batch fabrication.

3.Casting / Molding

Open cast on wafer; thickness & flatness vary

Closed-mold PDMS molding with calibrated pressure for thickness, planarity, and surface finish control.

5.Ports & Reservoirs

Manual punch/drill; debris & misalignment risk

Molded-in ports/reservoirs (no punching) or precision drilling with capture & clean protocols.

When to use which

  • Prototype & small batches (1–100 pcs/order): lab-style or hybrid for speed.

  • Pilot/bridge (100–500 pcs/order or <500 pcs/month): hybrid with selected closed-mold steps to boost yield.

  • High volume (≥500 pcs/month): HiComp closed-mold production for repeatability, cost, and scale.

HiComp PDMS Capabilities

Geometry & Features

Minimum channel width: ≥ 2 µm

Channel depth tolerance: ±5%

Channel aspect ratio: up to 10:1

Minimum through-hole diameter: 0.30 mm

Maximum chip size: up to 300 mm × 300 mm

QC& Logistics

  • Cleanroom: ISO 7 protocols

  • Particle control: microscopic inspection; debris-free in critical areas

  • Lead times: 2–3 weeks after design confirmation (expedites available)

  • MOQ: no strict MOQ; pricing improves with batch size

  • Maximum monthly capacity: up to 80,000 pcs/month

  • Deliverables: bare chips, chips with pre-assembled tubing,

        or fully integrated cartridge assemblies

Layers

  • Layer count: 2–8 layers

  • Alignment accuracy (typical): 0.10 mm (tighter available on request)

  • Thickness tolerance: up to ±5 µm (design-dependent)

  • Flatness: as low as 2 µm, maintained via closed-mold planarity controls

  • Color/tinting: clear (default) or tinted/colored PDMS

Bonding & Integration

  • Bonding options: bubble-free glass/PDMS and PDMS/PDMS bonding

  • Bond strength: > 60 psi

  • Temporary/reversible bonding: available on request

  • Integrated features: molded-in through-holes/reservoirs

  • Membranes & electrodes: bonded membranes; embedded electrodes supported

Why Choose Us

Integrated Mold
Integrated Mold  Closed mold, NOT SU-8 wafers.

Integrated Mold

 Closed mold, NOT SU-8 wafers. 

Precise Molding
Precise Molding   Molded, NOT casted.

Precise Molding

  Molded, NOT casted.

Scalable Pipeline
Scalable Pipeline  By technicians, NOT scientists.

Scalable Pipeline

 By technicians, NOT scientists. 

ISO standard

ISO 7
Cleanroom

ISO 13485 Certified

ISO 13485
Certified

FDA Registered

FDA
Registered

1M+ PDMS Chips Delivered

1M+ PDMS
Chips Delivered

Trusted by Global Leaders

Trusted by
Global Leaders

FAQ

Abstract White Waves

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Request a quote

Send a CAD file, a schematic or a paper. We reply with a DFM review and a quote.

Project stage
Prototype
Pilot batch / process verification
Production
Quantity (per month at production)
Fewer than 20
20–200
200–2,000
More than 2,000

By sending this, you agree that we may contact you about your inquiry. We do not add you to a mailing list.

Prefer to talk it through first? Book a design review →

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