Custom Microfluidic Devices for Drug Delivery

01 • THE CASE FOR MICROFLUIDIC DRUG DELIVERY

Why Microfluidics?
Four reasons microfluidic devices are revolutionizing pharmaceutical delivery systems for next-generation therapeutics.

Precision-controlled delivery
Microfluidic devices enable unprecedented control over drug formulation, particle size, and release kinetics, making them ideal for advanced therapeutics including lipid nanoparticles, biologics, and targeted delivery systems.

ADVANTAGES OVER CONVENTIONAL METHODS
• Enhanced mixing control for consistent particle formation
• Precise dosing with improved bioavailability
• Reduced manufacturing variability
• Scalable production from lab to commercial volumes
• Better compatibility with sensitive biologics

Therapeutic versatility
From inhaled medications to transdermal patches and implantable devices, microfluidic platforms adapt to diverse delivery routes and therapeutic modalities that conventional manufacturing cannot address.

KEY APPLICATION AREAS
• Lipid nanoparticle synthesis for mRNA and gene therapies
• Soft mist inhalation for pulmonary delivery
• Microneedle platforms for transdermal applications
• Sustained-release implantable systems
• Point-of-care therapeutic preparation

02 • MANUFACTURING EXCELLENCE

Integrated Development Path
HiComp combines prototyping capabilities with production-scale manufacturing to accelerate your journey from concept to commercial device.

Comprehensive technology stack
Our integrated approach eliminates the need for multiple suppliers, providing everything from initial PDMS prototypes to commercial-grade thermoplastic devices with full quality certification.

CORE CAPABILITIES
• PDMS rapid prototyping and validation
• COC and thermoplastic commercial production
• MEMS microstructure fabrication
• Multiple bonding technologies (thermal, ultrasonic, laser, solvent, PSA)
• ISO 7 cleanroom manufacturing environment
• ISO13485 and ISO9001 quality systems

03 • PROVEN SUCCESS STORIES

Case Studies
Real-world examples demonstrating our expertise in developing custom microfluidic solutions for pharmaceutical applications.

Lipid Nanoparticle Synthesis Platform
A biotech company needed to scale LNP production from lab-scale batch processing to continuous manufacturing for clinical trials.

HICOMP SOLUTION
• Designed custom mixing chambers for controlled lipid-aqueous phase interaction
• Developed pressure-resistant chip architecture for high-throughput production
• Transitioned from PDMS prototypes to COC commercial devices
• Implemented quality control systems for particle size consistency

RESULTS ACHIEVED
• 90% reduction in particle size variability
• 5x increase in production throughput
• Successful FDA IND submission
• Seamless scale-up to commercial manufacturing

Soft Mist Inhaler Core Module
Pharmaceutical company required precision aerosol generation for improved lung deposition of their respiratory medication.

HICOMP SOLUTION
• MEMS-fabricated microstructures for controlled droplet formation
• Optimized channel geometry for uniform aerosol characteristics
• Integrated functional testing throughout development
• Validated manufacturing processes for medical device production

RESULTS ACHIEVED
• Achieved target 1-5 μm particle size distribution
• Improved lung deposition by 40% vs conventional inhalers
• Met FDA requirements for inhaled drug delivery devices
• Established commercial production capabilities

04 • YOUR DEVELOPMENT PARTNER

Why Choose HiComp
More than a supplier—we're your strategic partner for transforming therapeutic concepts into market-ready delivery systems.

End-to-end partnership
From initial feasibility studies through commercial manufacturing, HiComp provides the expertise and infrastructure to support your entire development timeline.

PARTNERSHIP ADVANTAGES
• Single point of contact across all development stages
• Reduced time-to-market through integrated workflows
• Risk mitigation with proven development methodologies
• Regulatory support for medical device submissions
• Post-launch manufacturing and quality assurance