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PDMS Microfluidics
From Prototype to Production

  • HiComp delivers production-grade PDMS devices with a clean finish, precise thickness control, and injection molding level quality.

  • Support organ-on-chip, organoids, cell culture, diagnostics, liquid biopsy, and drug discovery with  speed and industrial-scale yield.

Applications

Organ-on-a-Chip
(OOC) & MPS

Organ-on-a-Chip

  • Gas-permeable and optically  clear

  • Bubble-free substrates preserve viability.

  • Electrode & membrane integration supported.

Organoids & 3D Cell Culture

Organoids

  • Soft, biocompatible interfaces; 

  • 2-8 layer bonding; 

  • Uniform thickness for imaging.

Liquid Biopsy

Liquid Biopsy

  • High-resolution, high-aspect-ratio replication

  • High fidelity microfeatures for capture/sorting.

Assay Development

Assay Development & Ramp-up

  • Rapid design iteration;

  • Multilayer bonding;

  • Various surface treatment; 

  • Ready to scale.

Process flow -Lab vs. HiComp at Scale

Typical Lab Setup

HiComp Production

single.png

Manual weigh & hand-mix; variable degassing

Metered mixing and controlled vacuum degassing in dedicated equipment for bubble free bulk PDMS and batch-to-batch consistency.

2.PDMS Mixing

 4.Bonding

PDMS Mixing

6.Assembly

Ports & Reservoirs
Bonding

Benchtop tubing; manual assembly

Single-piece plasma bonding by hand

Batch bonding in fixtures and high yield.

Documented assembly (tubing, membranes, electrodes) or cartridge integration for high-volume packaging.

Casting / Molding
Assembly

1.Master Mold

SU-8 photoresist on wafer; open tool; limited lifetime

Mother mold Tooling by using 3D printing, CNC, SU-8, and silicon etch; long-life resin master for batch fabrication.

3.Casting / Molding

Open cast on wafer; thickness & flatness vary

Closed-mold PDMS molding with calibrated pressure for thickness, planarity, and surface finish control.

5.Ports & Reservoirs

Manual punch/drill; debris & misalignment risk

Molded-in ports/reservoirs (no punching) or precision drilling with capture & clean protocols.

When to use which

  • Prototype & small batches (1–100 pcs/order): lab-style or hybrid for speed.

  • Pilot/bridge (100–500 pcs/order or <500 pcs/month): hybrid with selected closed-mold steps to boost yield.

  • High volume (≥500 pcs/month): HiComp closed-mold production for repeatability, cost, and scale.

HiComp PDMS Capabilities

Geometry & Features

Minimum channel width: ≥ 2 µm

Channel depth tolerance: ±5%

Channel aspect ratio: up to 10:1

Minimum through-hole diameter: 0.30 mm

Maximum chip size: up to 300 mm × 300 mm

QC& Logistics

  • Cleanroom: ISO 7 protocols

  • Particle control: microscopic inspection; debris-free in critical areas

  • Lead times: 2–3 weeks after design confirmation (expedites available)

  • MOQ: no strict MOQ; pricing improves with batch size

  • Maximum monthly capacity: up to 80,000 pcs/month

  • Deliverables: bare chips, chips with pre-assembled tubing,

        or fully integrated cartridge assemblies

Layers

  • Layer count: 2–8 layers

  • Alignment accuracy (typical): 0.10 mm (tighter available on request)

  • Thickness tolerance: up to ±5 µm (design-dependent)

  • Flatness: as low as 2 µm, maintained via closed-mold planarity controls

  • Color/tinting: clear (default) or tinted/colored PDMS

Bonding & Integration

  • Bonding options: bubble-free glass/PDMS and PDMS/PDMS bonding

  • Bond strength: > 60 psi

  • Temporary/reversible bonding: available on request

  • Integrated features: molded-in through-holes/reservoirs

  • Membranes & electrodes: bonded membranes; embedded electrodes supported

Why Choose Us

Integrated Mold
Integrated Mold Closed mold, NOT SU-8 wafers.

Integrated Mold

 Closed mold, NOT SU-8 wafers. 

Precise Molding
Precise Molding Molded, NOT casted.

Precise Molding

  Molded, NOT casted.

Scalable Pipeline
Scalable Pipeline By technicians, NOT scientists.

Scalable Pipeline

 By technicians, NOT scientists. 

ISO-7-logo

ISO 7
Cleanroom

ISO 13485 Certified

ISO 13485
Certified

FDA Registered

FDA
Registered

1M+ PDMS Chips Delivered

1M+ PDMS
Chips Delivered

Trusted by Global Leaders

Trusted by
Global Leaders

FAQ

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