Why Choose HiComp
Fast Turnaround
Chips delivered in two weeks
Biocompatible Materials
PDMS, Glass, & Thermoplastics
Reproducible Results
Standardized QC protocols
Physiologically Relevant
Human-mimetic microenvironment
500+ Projects Supported
Academic & Pharma Experience
Choose Your Service
How It Works
1
Consultation
We align on your biological target (Liver, Kidney, BBB, etc.) and choose the right chip format.
2
Setup & Culture
We fabricate the microfluidic devices and (for Full Service) establish the cell culture.
3
Validation
Rigorous QC: Leakage testing for chips; Functional barrier/toxicity checks for models.
4
Delivery
We ship your Ready-to-Use Chips (Starter) or your Final Data Report (Full Service).
Request a Proposal for OOC Model Development
Case Studies
Case Study 1
Microplate-Based NASH Liver Organoids:
A Platform for Hepatotoxicity Testing
We build custom microwell plates (6-well to 384-well) with engineered substrates and microfeatures to control spheroid/organoid formation and support high-quality imaging. The platform robustly discriminates hepatotoxic compounds (e.g., clozapine) with results that are consistent across multiple biological donors.
Manufacturing
Custom Microplate Platform
Custom microwells (down to 2 μm), diverse substrates (plastic, glass, hybrid), and custom pipette tips for precise, high-quality organoid formation and imaging.
Protocol
NASH Model Timeline (21 Days)
Day 0
Seed
Day 7
Induce NASH
Day 14
Drug Treatment
Day 21
Effect
Donor 1
Donor 2
Donor 3
Primary human hepatocytes co-cultured with stromal cells, consistent organoid formation and NASH induction across multiple donors.
Results
Robust Hepatotoxicity Testing
Donor 1
Donor 2
Donor 3
Clearly distinguishes hepatotoxic (Clozapine) from non-hepatotoxic (Amoxapine) compounds, yielding consistent results across all donors.
Case Study 2
Microfluidic Organ-on-a-Chip:
Advanced Tissue Barrier Modeling with Parylene C Membrane
Traditional organ-on-a-chip membranes (like PDMS, PC, or PET) often compromise physiological relevance due to excessive thickness, poor optical clarity, and small-molecule absorption that biases drug assays. Our proprietary Parylene C membranes overcome these fundamental challenges. By utilizing advanced MEMS fabrication, we provide ultrathin, highly porous, and transparent interfaces that enable superior barrier tissue modeling and high-content imaging.
Technology
Advanced Microfluidic Technology
Parylene-based PERFECT filter
Integrated PDMS devices with ultrathin, high-precision Parylene C "PERFECT" filters. Customizable pore sizes and tunable porosity (2-90%)
Performance
Superior Membrane Performance
Parylene C offers superior properties for high-fidelity barrier modeling.
Applications
Versatile Barrier & Coculture Models
Exposome Capture
Single-Cell Sorting
Tuberculosis Detection
CTC Capture/
Culture
Supports diverse models including tissue barriers, parenchymal tissue, and multi-organ interactions. Our platform enables complex co-cultures with precise control over cellular microenvironments, facilitating accurate modeling of physiological barriers and dynamic cellular interactions.