Why Choose HiComp
True One-Stop Partner
We manage the entire workflow from chip fabrication to biology. no vendor handoffs.
Fully Custom Solutions
Your science dictates the design. We customize every geometry and chemistry to your specific application.
Two-Week Rapid Iteration
Speed is innovation. Design, prototype, and iterate in as little as 2 weeks via our in-house foundry.
Modular Perfusion Systems
Plug-and-Play Integration. Automate your workflow with integrated pumps, sensors and optics.
Industrial Scalability
20 Million+ Chips Delivered.
We are the only partner capable of scaling PDMS devices to high volumes (10k+).
Full Service Solutions
How It Works
1
Consultation
We align on your biological target (Liver, Kidney, BBB, etc.) and choose the right chip format.
2
Setup & Culture
We fabricate the microfluidic devices and establish the cell culture system.
3
Validation
4
We perform rigorous QC (Leakage testing for chips; Functional barrier/toxicity checks for models) and functional verification.
Delivery
We ship your Ready-to-Use Chips (device) and your Final Data Report (validated data).
Request a Proposal for OOC Model Development
Case Studies
Case Study 1
Microplate-Based NASH Liver Organoids:
A Platform for Hepatotoxicity Testing
We build custom microwell plates (6-well to 384-well) with engineered substrates and microfeatures to control spheroid/organoid formation and support high-quality imaging. The platform robustly discriminates hepatotoxic compounds (e.g., clozapine) with results that are consistent across multiple biological donors.
Manufacturing
Custom Microplate Platform
Custom microwells (down to 2 μm), diverse substrates (plastic, glass, hybrid), and custom pipette tips for precise, high-quality organoid formation and imaging.
Protocol
NASH Model Timeline (21 Days)
Day 0
Seed
Day 7
Induce NASH
Day 14
Drug Treatment
Day 21
Effect
Donor 1
Donor 2
Donor 3
Primary human hepatocytes co-cultured with stromal cells, consistent organoid formation and NASH induction across multiple donors.
Results
Robust Hepatotoxicity Testing
Donor 1
Donor 2
Donor 3
Clearly distinguishes hepatotoxic (Clozapine) from non-hepatotoxic (Amoxapine) compounds, yielding consistent results across all donors.
Case Study 2
Microfluidic Organ-on-a-Chip:
Advanced Tissue Barrier Modeling with Parylene C Membrane
Traditional organ-on-a-chip membranes (like PDMS, PC, or PET) often compromise physiological relevance due to excessive thickness, poor optical clarity, and small-molecule absorption that biases drug assays. Our proprietary Parylene C membranes overcome these fundamental challenges. By utilizing advanced MEMS fabrication, we provide ultrathin, highly porous, and transparent interfaces that enable superior barrier tissue modeling and high-content imaging.
Technology
Advanced Microfluidic Technology
Parylene-based PERFECT filter
Integrated PDMS devices with ultrathin, high-precision Parylene C "PERFECT" filters. Customizable pore sizes and tunable porosity (2-90%)
Performance
Superior Membrane Performance
Parylene C offers superior properties for high-fidelity barrier modeling.
Applications
Versatile Barrier & Coculture Models
Exposome Capture
Single-Cell Sorting
Tuberculosis Detection
CTC Capture/
Culture
Supports diverse models including tissue barriers, parenchymal tissue, and multi-organ interactions. Our platform enables complex co-cultures with precise control over cellular microenvironments, facilitating accurate modeling of physiological barriers and dynamic cellular interactions.
FAQ
PDMS · Injection Molding · MEMS - One Partner
6195 Cornerstone Ct East, Suite 105, San Diego, CA 92121
858.252.5959