Why Choose HiComp
Pharma-Led Expertise
A specialized biology team under the leadership with extensive ex-big pharma and CRO experiences, ensuring all models meet rigorous industry benchmarks.
Adaptive Customization
Rapid, proprietary design-to-prototype workflows that drastically shorten R&D cycles through hyper-fast iteration.
Two-Week Rapid Iteration
Speed is innovation. Design, prototype, and iterate in as little as 2 weeks via our in-house foundry.
Versatile Portfolio
An application-centric platform supporting a wide range of organ types and therapeutic areas to capture maximum market demand.
Scalable In-House Manufacturing
Fully integrated production ensuring industrial-scale supply, rigorous quality control, and IP security.
Custom Organ-on-a-Chip Devices and Systems
Request a Proposal
How It Works
1
Consultation
We align on your biological target (Liver, Kidney, BBB, etc.) and choose the right chip format.
2
Setup & Culture
We fabricate the microfluidic devices and establish the cell culture system.
3
Validation
4
We perform rigorous QC (Leakage testing for chips; Functional barrier/toxicity checks for models) and functional verification.
Delivery
We ship your Ready-to-Use Chips (device) and your Final QC Data Report.
Case Studies
Case Study 1
Microplate-Based NASH Liver Organoids:
A Platform for Hepatotoxicity Testing
We build custom microwell plates (6-well to 384-well) with engineered substrates and microfeatures to control spheroid/organoid formation and support high-quality imaging. The platform robustly discriminates hepatotoxic compounds (e.g., clozapine) with results that are consistent across multiple biological donors.
Manufacturing
Custom Microplate Platform
Custom microwells (down to 2 μm), diverse substrates (plastic, glass, hybrid), and custom pipette tips for precise, high-quality organoid formation and imaging.
Protocol
NASH Model Timeline (21 Days)
Day 0
Seed
Day 7
Induce NASH
Day 14
Drug Treatment
Day 21
Effect
Donor 1
Donor 2
Donor 3
Primary human hepatocytes co-cultured with stromal cells, consistent organoid formation and NASH induction across multiple donors.
Results
Robust Hepatotoxicity Testing
Donor 1
Donor 2
Donor 3
Clearly distinguishes hepatotoxic (Clozapine) from non-hepatotoxic (Amoxapine) compounds, yielding consistent results across all donors.
Case Study 2
Microfluidic Organ-on-a-Chip:
Advanced Tissue Barrier Modeling with Parylene C Membrane
Traditional organ-on-a-chip membranes (like PDMS, PC, or PET) often compromise physiological relevance due to excessive thickness, poor optical clarity, and small-molecule absorption that biases drug assays. Our proprietary Parylene C membranes overcome these fundamental challenges. By utilizing advanced MEMS fabrication, we provide ultrathin, highly porous, and transparent interfaces that enable superior barrier tissue modeling and high-content imaging.
Technology
Advanced Microfluidic Technology
Parylene-based PERFECT filter
Integrated PDMS devices with ultrathin, high-precision Parylene C "PERFECT" filters. Customizable pore sizes and tunable porosity (2-90%)
Performance
Superior Membrane Performance
Parylene C offers superior properties for high-fidelity barrier modeling.
Applications
Versatile Barrier & Coculture Models
Exposome Capture
Single-Cell Sorting
Tuberculosis Detection
CTC Capture/
Culture
Supports diverse models including tissue barriers, parenchymal tissue, and multi-organ interactions. Our platform enables complex co-cultures with precise control over cellular microenvironments, facilitating accurate modeling of physiological barriers and dynamic cellular interactions.
FAQ
PDMS · Injection Molding · MEMS - One Partner
6195 Cornerstone Ct East, Suite 105, San Diego, CA 92121
858.688.0000